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KMID : 1040620150210020180
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Clinical and Molecular Hepatology
2015 Volume.21 No. 2 p.180 ~ p.182
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Liver dysfunction induced by systemic hypersensitivity reaction to lamotrigine
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Im Sung-Gyu
Yoo Sun-Hong
Park Young-Min
Lee Sang-Jin
Jang Sun-Kyung
Jeon Dong-Ok
Cho Hyo-jin
Oh Mi-Jung
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Abstract
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Lamotrigine is an anticonvulsant drug used to treat partial and generalized seizure disorders. Hypersensitivity to lamotrigine usually causes mild symptoms such as fever, rash, and slight invasion of internal organs. However, a 33-year-old male patient who was admitted with Stevens-Johnson syndrome after taking lamotrigine for 15 days experienced hepatic failure and died 5 days after admission. This case demonstrates the importance of realizing that lamotrigine can lead to fatal hepatic failure, and that tests for the normal liver function should be performed when administering lamotrigine.
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KEYWORD
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Lamotrigine, Hypersensitivity, Hepatotoxicity
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